The loss of bees would also cost us honey, a foodstuff that throughout human history has been much more than a pleasant sugar-substitute. Energy-dense, nutritionally-rich wild honey, ideal for brain development, may have helped our earliest human ancestors along the path of evolution. The importance of honey foraging can be inferred from its frequent appearance in Paleolithic art. The Araña Caves of Valencia, Spain, are notable for a particularly evocative line drawing of a honey harvester dangling precariously while thrusting an arm into a beehive.

Honey is easily fermented, and there is evidence that the ancient Chinese were making a mixed fruit, rice and honey alcoholic beverage as early as 7000 BC. The Egyptians may have been the first to domesticate bees. A scene in the sun temple of Pharaoh Nyuserre Ini, built around 2400 B.C., depicts beekeepers blowing smoke into hives as they collect honey. They loved the taste, of course, but honey also played a fundamental role in Egyptian culture. It was used in religious rituals, as a preservative (for embalming) and, because of its anti-bacterial properties, as an ingredient in hundreds of concoctions from contraceptives to gastrointestinal medicines and salves for wounds.

The oldest known written reference to honey comes from a 4,000-year-old recipe for a skin ointment, noted on a cuneiform clay tablet found among the ruins of Nippur in the Iraqi desert.

The ancient Greeks judged honey like fine wine, rating its qualities by bouquet and region. The thyme-covered slopes of Mount Hymettus, near Athens, were thought to produce the best varieties, prompting sometimes violent competition between beekeepers. The Greeks also appreciated its preservative properties. In 323 B.C., the body of Alexander the Great was allegedly transported in a vat of honey to prevent it from spoiling.